The neighbors of Luis Toledo testified Friday they heard a woman screaming the night his wife disappeared.

Luis Toledo is accused of killing his wife, Yessenia Suarez, and her two children, Thalia and Michael Otto, in October 2013. Their bodies have never been found.

Two teenagers who used to live near the Toledo/Suarez home testified Friday they heard noises coming from the direction of their home early on Oct. 23.

"I was woken up around 12:30 a.m. and I could hear a woman yelling, 'Help me,'" one of the teenagers said. "I was woken up by it two or three times."

Per our crime guidelines, News 13 is not identifying the two young witnesses.

The teenagers claim they went back to sleep after the screams stopped, thinking it was just a few kids from the neighborhood shouting.

The next morning they woke up to see their neighbor's home surrounded by police and found out that Suarez and her children, 8-year-old Michael and 9-year-old Thalia, were all missing.

The teenagers testified they also came across a large knife near near their neighbor's home. They later turned that over to police and told the police about the screams when they got home from school.

"I told them, I was wide awake and I heard someone screaming, 'Help me,'" another one of the teenagers testified.

Forensic experts offered an explanation for the disappearance of the woman and children. They explained the blood spatter pattern found in various areas of the home show something "very impactful" happened there.

"I observed the stains and I determined the stains were left there by using forceful impact," said former Florida Department of Law Enforcement Crime Scene analyst and expert Leroy Parker.

Jurors have been sent home for the weekend, and the trial resumes Monday.